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- Constituted 21 December 1928 as 6th Medical Supply Depot at Ft. Sam Houston, TX
- Activated 25 May 1942 for service in WW II
- Served as the only Medical Supply Activity for the first 13 months of the Korean War beginning September 1950
- Relocated from Yongsan to Camp Carroll 1988 as the 6th MEDSOM
- Re-organized as the 16th Medical Logistics Battalion on 16 September 1993
- Re-organized as the U.S. Medical Materiel Center - Korea on 16 October 2009
- Re-aligned under U.S. Army Medical Logistics Command as a direct-reporting unit 17 September 2019
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